Anthelmintic Properties of Methanol Extract of Bridelia micrantha (Hochst) Baill Leaves

Philip Asumang; Yaw Duah Boakye Duah Boakye; William Gariba Akanwariwiak Gariba Akanwariwiak; Francis Adu Adu; Jibira Yakubu Yakubu; Philomena Entsie  Entsie; Emmanuel Oppong Oppong; Job Donkor Donkor; Emmanuel Amihere Cobbinah Amihere; Gadafi Iddrisu Balali Iddrisu; Vera Afua Dela Gobe Gobe

doi:10.37256/amtt.3220221515

Authors

Philip Asumang Department of Theoretical and Applied Biology, College of Science, Kwame Nkrumah University of Science and Technology, Ghana https://orcid.org/0000-0002-2471-9357
Yaw Duah Boakye Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Ghana
William Gariba Akanwariwiak Department of Theoretical and Applied Biology, College of Science, Kwame Nkrumah University of Science and Technology, Ghana
Francis Adu Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Ghana
Jibira Yakubu Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Ghana
Philomena Entsie Department of Herbal Medicine, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Ghana
Emmanuel Oppong Department of Crop and Soil Sciences, Faculty of Agriculture, Kwame Nkrumah University of Science and Technology, Ghana
Job Donkor Department of Science Education, Seventh-Day Adventist College of Education, Agona-Ashanti, Ghana
Emmanuel Amihere Cobbinah Department of Science Education, Seventh-Day Adventist College of Education, Agona-Ashanti, Ghana
Gadafi Iddrisu Balali Department of Theoretical and Applied Biology, College of Science, Kwame Nkrumah University of Science and Technology, Ghana
Vera Afua Dela Gobe Department of Theoretical and Applied Biology, College of Science, Kwame Nkrumah University of Science and Technology, Ghana

DOI:

https://doi.org/10.37256/amtt.3220221515

Keywords:

Bridelia micrantha, anthelminthic activity, potentiation

Abstract

Helminths in recent times are said to be highly resistant to anthelmintic therapeutics. The level of attention paid to this area is quite low, therefore causing a serious threat to humans and livestock. Helminth's infection is rampant in developing countries contributing significantly to economic losses and food security in general. This study aims to determine the Anthelmintic properties of methanol extract of Bridelia micrantha (Hochst) Baill leaves. Methods: The anthelmintic activity of helminths was determined by exposure to various concentrations of reference anthelminthic (albendazole, praziquantel and mebendazole) drugs and plant extract. Measurements were taken based on times for death and paralysis. Results: The extract exhibited a concentration-dependent anthelmintic activity against Lumbricus terrestris with significant (p < 0.0001) paralysis and death times when the extract concentrations were 4, 8, 16 and 32 mg/mL respectively. In the presence of 0.125 mg/mL of the extract the reference anthelmintic (albendazole), showed a potentiated activity against the test organism. In the presence of 0.25 mg/mL of the extract the reference anthelmintic (mebendazole), also showed a potentiated activity against the test organism. In the presence of 0.125 and 0.25 mg/ml of the extract, the reference anthelmintic (praziquantel) showed similar results. Conclusion: The extract had anthelmintic activity against L. terrestris and modified the resistance of the organism to albendazole, mebendazole and praziquantel.

Anthelmintic Properties of Methanol Extract of Bridelia micrantha (Hochst) Baill Leaves

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