Dynamics of HIV-1 and HTLV-1 Coinfection with both CTL and Antibody Responses

Authors

  • Ahmed M. Elaiw Department of Mathematics, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia
  • Noura H. AlShamrani Department of Mathematics and Statistics, Faculty of Science, University of Jeddah, P.O. Box 80327, Jeddah 21589, Saudi Arabia
  • Amani S. AlSulami Department of Mathematics, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia
  • Aatef D. Hobiny Department of Mathematics, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia

DOI:

https://doi.org/10.37256/cm.5220243870

Keywords:

HIV-1/HTLV-1 coinfection, global stability, Lyapunov function, immune response

Abstract

Human immunodeficiency virus type 1 (HIV-1) and human T-lymphotropic virus type 1 (HTLV-1) coinfection models with simply an antibody response or a CTL response have been the subject of several recent investigations. Thus, the primary objective of this paper is to formulate and examine a mathematical framework for analyzing the intricate dynamics of coinfection between HIV-1 and HTLV-1. The model takes into account the role of antibody response against free HIV-1 particles and CTL response against HTLV-1-infected cells. We prove that the model is well-posed and it admits eight equilibria. The stability and existence of the equilibria are precisely controlled by eight threshold parameters ℜi, i = 1, 2, ..., 8. By formulating suitable Lyapunov functions and applying LaSalle's invariance principle, we show the global asymptotic stability for all equilibria. To demonstrate the theoretical results, we conduct numerical simulations. We look at how the antibody and CTL responses affect the dynamical behavior of HIV-1/HTLV-1 coinfection. Although the parameters of antibody and CTL responses have no effect on the basic reproduction ratio of HIV-1 single-infection (ℜ₁) and HTLV-1 single-infection (ℜ₂), it has been demonstrated that viral coinfection can be inhibited by immunological activation of antibody and CTL responses. This could potentially facilitate the advancement of therapeutic approaches for HIV-1 and HTLV-1, which have the capability to enhance the HIV-1-specific antibody and HTLV-1-specific CTL reactions.

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Published

2024-04-15

How to Cite

1.
Elaiw AM, AlShamrani NH, AlSulami AS, Hobiny AD. Dynamics of HIV-1 and HTLV-1 Coinfection with both CTL and Antibody Responses. Contemp. Math. [Internet]. 2024 Apr. 15 [cited 2024 May 28];5(2):1606-44. Available from: https://ojs.wiserpub.com/index.php/CM/article/view/3870