Exploring the Chemistry, Reactions, Applications, and Biomedical Potentials of 2-Nitrobenzaldehyde and 2-Chlorobenzaldehyde

Abstract

This article investigates the diverse chemical reactions and applications of 2-nitrobenzaldehyde, exploring its versatility in synthetic organic chemistry. The focus is on key reactions such as reduction to yield 2-aminobenzaldehyde, Schiff base synthesis with primary amines, Michael addition reactions, Sandmeyer reaction for the formation of 2-nitrobenzoic acid, selenium dioxide oxidation to 2-nitrobenzoic acid, and condensation reactions leading to benzanthrone derivatives. Each reaction pathway is discussed along with its potential applications in various fields. The second part of the review shifts the spotlight to 2-chlorobenzaldehyde, emphasizing its physical and chemical properties. Further exploration of 2-chlorobenzaldehyde's chemical reactivity reveals its engagement in nucleophilic addition reactions, alcoholysis reactions, acetylation reactions, reductive amination reactions, Witting reactions, and halogenation reactions. These reactions showcase the compound's adaptability and utility in diverse synthetic pathways. This article also discusses the biomedical application of 2-chlorobenzaldehyde and 2-nitrobezaldehyde.