A Recent Trends on Green Synthesis and Bioactivity of Imidazole

Abstract

Imidazole is a five-membered, planar heterocyclic ring made up of 3C, 2N, and N in the 1st and 3rd places. Purine, histamine, histidine, and nucleic acid are only a few significant natural compounds that contain the imidazole ring. It is utilised as a cure to optimize the solubility and bioavailability properties of proposed weakly soluble lead compounds since it is an aromatic chemical that is polar and ionizable and so improves the pharmacokinetic features of lead molecules. Derivatives of imidazole have a special place in medicinal chemistry. An essential synthesis technique in the process of discovering new drugs is the integration of the imidazole nucleus. Due to the remarkable therapeutic efficacy of medications related to imidazole, medicinal chemists have been inspired to create numerous innovative chemotherapy agents. This review summarized the work that has been done in recent years about different synthetic approaches of imidazole derivatives and their potential activity as anti-HIV, anticancer, anticovid, antifungal, antidiabetic, antidepressant, antioxidant, and antituberculosis.