A Mononuclear Nickel(II) Complex: Synthesis, X-ray Structure, Spectroscopic Characterization and Anti-tumor Activity

Sangharaj  Diyali; Ayan Kumar  Mohanty; Subhajit  Sarkar; Md. Firoj  Hossain; Biplab  Bhowmik; Bhaskar Biswas

doi:10.37256/acbr.112022752

A Mononuclear Nickel(II) Complex: Synthesis, X-ray Structure, Spectroscopic Characterization and Anti-tumor Activity

Authors

Sangharaj Diyali Department of Chemistry, University of North Bengal, Darjeeling 734013, India
Ayan Kumar Mohanty Department of Biotechnology, University of North Bengal, Darjeeling 734013, India
Subhajit Sarkar Department of Chemistry, University of North Bengal, Darjeeling 734013, India
Md. Firoj Hossain Department of Chemistry, University of North Bengal, Darjeeling 734013, India
Biplab Bhowmik Department of Zoology, Diamond Harbour Women's University, West Bengal 743368, India
Bhaskar Biswas Department of Chemistry, University of North Bengal, Darjeeling 734013, India

DOI:

https://doi.org/10.37256/acbr.112022752

Keywords:

nickel (II), 2,2'-bipyridine, crystal structure, anti-tumor activity

Abstract

In this work, an effort has been made to examine the counteranionic behavior of thiocyanide ion towards the stabilization of a dicationic tris(2,2'-bipyridine)nickel(II) complex in crystalline phase. The complex, [Ni(bipy)₃]^.2NCS (1) [bipy = 2,2'-bipyridine] was designed, synthesized and structurally characterized. The crystal structure analysis reveals that 1 crystallises in a hexagonal system with P6/mcc space group and adopts an octahedral geometry. The nickel(II) complex exhibits important cytotoxic behaviour towards lung cancer cell (A549). IC₅₀value is calculated through MTT assay and determined as 131 µG/mol. Relative percentage of morphological changes is further determined and ~63% of the cells are destroyed through apoptosis mode with in 24 h incubation.

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Published

2021-02-23

How to Cite

Diyali S, Mohanty AK, Sarkar S, Hossain MF, Bhowmik B, Bhaskar Biswas. A Mononuclear Nickel(II) Complex: Synthesis, X-ray Structure, Spectroscopic Characterization and Anti-tumor Activity. Advanced Chemicobiology Research [Internet]. 2021 Feb. 23 [cited 2024 Apr. 27];1(1):22-30. Available from: https://ojs.wiserpub.com/index.php/ACBR/article/view/752

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Issue

Advanced Chemicobiology Research, Volume 1 Issue 1 (2022)

Section

Research Article

License

This work is licensed under a Creative Commons Attribution 4.0 International License.